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Learn about prescription and over-the-counter medicine - how they work, possible side effects, and more. In bicalutamide alternative , your doctor could watch your blood sugar during your therapy. what is bicalutamide examine adopted girls with breast cancer who were given chemotherapy with or with out PSK. People who obtain palliative care along with therapy for the most cancers typically have less severe symptoms, higher quality of life, and report they are more happy with remedy.
Beck AM, Robinson JW, Carlson LE. Sexual intimacy in heterosexual couples after prostate cancer treatment: What we know and what we still need to study. Nonetheless, the problems with bicalutamide and different generic medicines were going on for months.
When you really feel you could have skilled an allergic reaction, stop utilizing this medication and inform your doctor or pharmacist immediately. Androgens gas the growth of prostate cells, including prostate most cancers cells. Nazi, K. M. generic for bicalutamide
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The Personal Well being Report Paradox: Health Care Professionals' Perspectives and the Data Ecology of Private Well being Report Systems in Organizational and Scientific Settings.” Journal of Medical Web Research 15, no. four (2013): e70.
For those who need remedy or medical recommendation, seek the advice of a competent and trustworthy medical doctor. CASODEX is indicated to be used in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analogue for the therapy of Stage D 2 metastatic carcinoma of the prostate.
Advise sufferers to inform their healthcare provider of any bleeding or spontaneous bruising while on CASODEX and taking anticoagulants see Warnings and Precautions (5.2) and Hostile Reactions (6.2).Glucose Tolerance: Inform sufferers that diabetes or loss of glycemic control in patients with pre-existing diabetes has been reported during therapy with LHRH agonists.
This article discusses the pharmacology, tolerability, and administration of these therapies and their efficacy as monotherapy or as neoadjuvant or adjuvant remedy, across the progressive stages of prostate most cancers. BCR is taken into account advanced most cancers, so testosterone suppression therapy may be recommended, particularly if other local treatments aren't doable.
Li R, Wheeler T, Dai H, Frolov A, Thompson T, Ayala G. cheap bicalutamide online of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer sufferers handled with radical prostatectomy.
The cost of medicines is not always inflated at the pharmacy. Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patients with follicular lymphoma with a low tumor burden: clinical and molecular analysis. Employers cover a population that is more healthy than either Medicare or Medicaid, and virtually all lined employees have protection for prescribed drugs.
In patients with multiple myeloma, the mixture of lenalidomide with dexamethasone is related to an increased threat of venous thromboembolism (predominantly deep vein thrombosis and pulmonary embolism) and was seen to a lesser extent with lenalidomide together with melphalan and prednisone.
Doctors give constructive suggestions about Revlimid, as it has been shown to be efficient in treating myeloma. The European Medicines Company concluded that, in accordance with EU requirements, Lenalidomide Accord has been proven to have comparable high quality and to be bioequivalent to Revlimid.
revlimid active ingredient : Medicare helps pay for antigens in the event that they're ready by a health care provider and are given by a properly instructed person (who might be you, the affected person) below appropriate supervision. In the U.S., BiCNU as been used for the remedy of multiple myeloma, lymphoma, mind tumors, malignant melanoma , breast cancer , and gastrointestinal cancer , among other indications.
Generic medicines are similar as branded medicines, even the corporate that makes branded medicines producers generic version however with a cheaper price. Elevated threat of getting an infection is because of a drop in white blood cells. As over the counter equivalent to revlimid of Revlimid can increase the risk of blood clots within the legs and lungs, patients taking Revlimid also obtain a blood thinner (anticoagulant) resembling aspirin or heparin.
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buy lenalidomide canada improved development-free survival (median 26 months vs 21 months from begin of induction, HR 0.70, 95% CI 0.60-0.eighty one) but there was no difference in overall survival (median fifty nine.1 months vs 62.three months, 1.02, zero.86-1.20).
Subsequently, these medications can cause comparable unintended effects. The notion of applying a worth framework to tell drug prices is not unfamiliar in the U.S., however it's presently stored behind a curtain. eleven We report on a randomized, phase 3 trial through which lenalidomide plus dexamethasone was compared with placebo plus dexamethasone in patients with relapsed or refractory multiple myeloma.
Bicalutamide belongs to a bunch of medications often known as nonsteroidal antiandrogens. how many casodex can i take in a day et al. casodex without a prescription
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casodex medication of metastatic and prostate particular antigen progression in patients with prostate most cancers: findings from a retrospective evaluation of well being plan information. I prescribe hormone remedy until the PSA reaches its lowest point (nadir), and that nadir is maintained for a month.
Therefore, in bicalutamide prescribing information , deciding which agent should be used as first-line remedy for sufferers with CRPC has been problematic. 1. Smith MR, Borre M, Rathenborg P, et al: Efficacy and security of enzalutamide monotherapy in hormone-naive prostate most cancers.
Binarex tablets 50mg include bicalutamide, a non-steroidal anti-androgen, which acts as a testosterone analogue as it is related in structure to testosterone and binds to the same receptor in prostate cells however with out activating any regular testosterone actions.
Bicalutamide shouldn't be utilized in patients with jaundice or elevated ALT ranges. over the counter bicalutamide showing mean PSI ranges for a panel of ESRP-regulated exons in prostate most cancers cell traces (CWR22RV1, PNT2, LNCaP and PC3). Fakih MG, Trump DL, Muindi JR, et al.: A phase I pharmacokinetic and pharmacodynamic examine of intravenous calcitriol together with oral gefitinib in sufferers with advanced solid tumors.
In a separate programme, the efficacy of Casodex one hundred fifty mg for the therapy of sufferers with regionally advanced non-metastatic prostate cancer for whom speedy castration was indicated, was demonstrated in a mixed analysis of 2 research with 480 beforehand untreated sufferers with non-metastatic (M0) prostate most cancers.
Bayer will this week declare an important prize for its multi-kinase inhibitor Stivarga as the brand new customary of care for second-line remedy of unresectable hepatocellular carcinoma. This order might elevate critical concerns to patent holders, especially of medication. nexavar generic and brand name has failed in the first stage of its bid to stop Indian group Natco from selling a rock-bottom-priced version of its liver and kidney cancer drug Nexavar in India.
Athar U, Gentile TC. Remedy options for metastatic renal cell carcinoma: a evaluation. Thus, generic sorafenib (i.e., INCREASE trial) are going to define its role in decompensated population sooner or later and up till then, affected person choice in patients treated with Sorafenib is important.
cheapest place to buy nexavar needs to be cautioned that exterior of the slender confines of randomized trials, their life expectancy could also be very quick, and any benefit of sorafenib is prone to be fairly small. There are many more drugs in this class, so it is very important learn the directions totally prior to your use of Nexavar.
Among the 1L (all) cohort, 38% of patients had HCV only, 5.8% had HBV only, and a pair of.four% had each HCV and HBV; an analogous distribution was found in the 1L (sorafenib) subcohort and the 2L cohort. This is able to essentially mean that NATCO could launch the generic Copaxone - by way of its advertising associate - Mylan Inc., during Might 2014, topic to FDA approval.
Outcomes: Fifty-nine patients obtained sorafenib in the examine period and the median general survival was 7 months (25-seventy five percentile =three-15 months). is there a generic for sorafenib
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Surveillance is associated with improved survival, but participation rates are low (forty%), despite 89% of patients with HCC qualifying for surveillance.
There have been no important differences between the 2 mixture remedy teams in terms of total hospital costs; nonetheless, the cost of admission was lower for the TACE-JD group in contrast with the TACE-SOR group, which may be defined by the low price of Chinese herbs compared with the excessive value of sorafenib.
GlobalData analyst masking oncology Melina Reisenberg says the event of recent remedies for hepatocellular carcinoma has been difficult, and no new drugs have entered the sector since the launch of Nexavar in 2007. The researchers imagine that taking the medication in combination could mean that patients might take Sorafenib in smaller doses, reducing the unfavourable penalties of unwanted effects.
A mix of an oral drug, known as sorafenib, and a way for injecting microbeads of chemotherapy immediately into tumors has been proven safe for liver cancer sufferers and should enhance outcomes for individuals who have these quick-growing, deadly tumors whose numbers are on the rise within the United States.
The small molecule multikinase inhibitor sorafenib remains the one molecularly targeted therapy accepted by the FDA for the remedy of hepatocellular carcinoma, with ongoing medical trials diligently testing the potential for novel targeted agents or combination therapies to additional improve affected person outcomes in this setting.
Basheer mentioned it was up to Bayer to ensure its patent was not revoked and that it undertook vital price reduction if the number of sufferers who may afford the drug didn't increase. sorafenib over the counter ought to use effective contraception during treatment with this medication and for at the least 6 months after the last dose.
Beneficiaries from the NexPAP patient assistance programme for treatment of liver most cancers have fun their ‘second-probability' in life. Abbreviations: CCK-8, cell counting package-eight; ctrl, management; HMSNs, hollow mesoporous silica nanoparticles; Tf-HMSNs, transferrin-conjugated HMSNs. can i buy sorafenib over the counter , Yan Z, Liu R, Shi P, Qian S, Qu X, Zhu L, Zhang W, Wang J. nexavar alternative of transcatheter arterial chemoembolization (TACE) with ginsenoside Rg3 versus TACE alone for the therapy of sufferers with superior hepatocellular carcinoma.
Advise sorafenib what does it do of reproductive potential to use effective contraception during treatment with OPDIVO or YERVOY and for a minimum of 5 months after the final dose. In DTC sufferers, a drop in imply Tg levels was observed at 3 months but was not sustained and by 9 months the mean Tg returned to baseline levels.
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Please consult together with your doctor for recommendations particular to your body, health and other drugs that you could be be utilizing. Bayer’s lawyer mentioned his client refused the voluntary licence as Natco’s strategy was not appropriate” and the correspondence on this regard implied a tone of a menace” that it may search a compulsory licence.
A total of eighty five sufferers (49 in the sorafenib group and 36 within the placebo group) were included in the assessment of safety with the usage of CTCAE, version 4.0. A abstract of the most typical adverse events is provided in Table 2 Adverse occasions led to a considerably greater fee of discontinuation of the trial routine in the sorafenib group than within the placebo group (20% vs. no sufferers).
Although early HCCs with single lesion less than 5 cm or a number of HCCs that are less than three in number and fewer than 3 cm each are becoming more successfully managed with different remedy modalities, together with hepatic resection, ablative therapy (radiofrequency ablation and percutaneous ethanol injection) and orthotropic liver transplantation, management of superior HCC stays a problem to physicians.
Within the closing matched cohorts, intermediate stage sufferers undergoing TARE and sorafenib yielded imply survivals of 24.0 (median 18.5) and 18.4 months (median thirteen.zero), respectively. expired nexavar to the previous experience with aspect-results, his children were initially against the beneficial remedy.
Systemic therapy is the present normal of take care of superior-stage disease. You shouldn't use Nexavar if you are allergic to sorafenib, or when you have squamous cell lung most cancers and you're being treated with carboplatin and paclitaxel. The above findings also suggested that HCC cells cope with the oxidative stress induced by Sorafenib remedy by increasing the expression of PHGDH.
Thus, not all advances are building blocks for the longer term, and this expectation should not justify expenditures for marginal advantages in patients with advanced disease. One of these treatment blocks the growth and spread of cancer cells while limiting injury to wholesome cells.
Indeed, part II clinical trials evaluating the efficacy and safety of numerous different brokers as monotherapy, together with sunitinib fifty two , cetuximab fifty three , erlotinib fifty four , fifty five , and bevacizumab 56 , have all been reported ( Desk 2 ), and a section III study of sorafenib together with erlotinib is in progress.
Researchers have revealed the highest 10 medicine by annual revenue in 2025. After an permissible druggist agency following studies had been passed: i. francois, was essential and it was given out by his generic gentamicin subsequent day supply As you might be instructive, i'm going further, and say that nicely first should quotations to not the allotting and report of experiments be applied to the exports dentist carried on at woods' males and all yellowish docs and sneakers where requtreo is disbursed, but that liabilities misapprehension ought to be carried out volubly by the liquid committee, but by a prepared use.
Below its compassionate release program, Calgene will make Thalomid and one other of its drugs, Revlimid - additionally for a number of myeloma - available to individuals who can't afford to pay for the drugs. Since its launch as a third line therapy for multiple myeloma in 2013, Pomalyst has turn into one of the indications top promoting medicine.
For generic lenalidomide side effects of multiple myeloma in sufferers who have acquired 1 to three prior therapies, in combination with elotuzumab and dexamethasone†. No dose adjustment is proposed for patients older than seventy five years who're handled with lenalidomide together with melphalan and prednisone.
Finally, adjusted ITCs were conducted primarily based on the relative results of each drug against a standard comparator following the tactic proposed by Bucher et al.17 The software CIT, developed by the Canadian Agency for Medication and Technologies in Well being (CADTH), was used to calculate the danger ratio (HR and RR) (95% CI)17,18.
does medicare cover lenalidomide of the insurance premium are extra of an abstract consideration when patients take into account coverage plans in the case of catastrophic sickness, normally without the prior knowledge of specific wants. 2 All grade 3 or four therapy-emergent AEs in at least 1% of patients within the REVLIMID + rituximab group and at the least 1% larger frequency (%) than the rituximab + placebo group (control arm).
Physicians at the moment are conducting clinical trials of thalidomide in the United States and Europe to find out if treatment is secure and well tolerated along side Riluzole. Before you start the Revlimid 15 mg capsule (Lenalidomide) drug, it is needed that you just inform your doctor the medical conditions you suffer.
They might want to retain good benefits for his or her workforce, however Bishop says employers understand that raising deductibles and rising co-pays on medications (enabling them to maintain wealthy benefit plans) end result solely in employees paying extra for medication and other healthcare providers.
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Adopting other countries' drug costs may assist align U.S. spending on drugs with worth—what we get in return. The identical will be mentioned for different reductions and assist for customers funded by pharmaceutical companies — for example, producers' coupons for model-title medicine with excessive sticker prices.
Your doctor has advisable a medicine referred to as Casodex as therapy on your prostate cancer. ADT utilises drugs to inhibit gonadal and further-gonadal androgen biosynthesis and competitive AR antagonists to dam androgen binding and abrogate AR perform ( Livermore et al., 2016 ). ADT delays illness development, however after 2-3 years tumours usually grow once more, creating castration resistance with a median survival time of sixteen months ( Karantanos et al., 2013 ). The central role of androgens and the AR in prostate most cancers, and the poor scientific outlook of castration-resistance prostate cancer (CRPCa), have made it crucially vital to determine androgen-regulated goal genes and mechanisms of function -particularly people who relate to metastasis.
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The incidence of gastrointestinal adversarial occasions among sufferers receiving bicalutamide eighty mg was lower than predicted from studies with bicalutamide 50 mg mixture remedy in Caucasians, 5 but mirrored the low incidence reported in the earlier evaluation of our study.
As online doctor casodex et al. ( 15 ) reported that Japanese males had better outcomes from hormonal therapy than did Caucasian males, and Namiki et al. ( sixteen ) reported that Japanese patients who underwent ADT did not increase their danger of heart problems, hormonal remedy is especially acceptable for Japanese sufferers.
Casodex is used to treat prostate cancerThis medication should never be taken by a lady or a child. By lowering the amount of testosterone in the physique, the growth and spread of prostate cancer may be slowed. Figure three.27. casodex no prescription between the binding modes of testosterone and bicalutamide to the androgen receptor.
Outcomes: The median development-free survival in sufferers handled with abiraterone was shorter in those with ≤18 months' response to LHRHa (118 vs. 279 days; p=0.018), bicalutamide non-responders (ninety one vs. 196 days; p=zero.003) and patients with ≤6 months' response to docetaxel (102 vs. 294 days; p
Vc_rowvc_columnvc_ bicalutamide online with credit card buy develops when there's an uncontrolled progress of cells within the prostate, a gland in the male reproductive system. The hazard ratio for time to development of CASODEX plus LHRH analog to that of flutamide plus LHRH analog was 0.93 (ninety five% confidence interval, zero.79 to 1.10).Determine 2 - Kaplan-Meier curve for time to progression for both antiandrogen remedy groups.Quality of life was assessed with self-administered patient questionnaires on ache, social functioning, emotional well-being, vitality, exercise limitation, mattress disability, overall well being, bodily capacity, basic signs, and remedy associated symptoms.
Males who've a female associate who can develop into pregnant should use effective birth control throughout therapy with CASODEX and for a hundred thirty days after the ultimate dose. Sufferers who're hypersensitive to gonadotropin-releasing hormone (GnRH), GnRH agonist analogs or any of the excipients in LUPRON DEPOT.
Please see the total Prescribing Information for Lupron Depot and focus on it with your doctor. dispenses medicines by way of our affiliated Canadian meting out pharmacy which is licensed in the province of Manitoba, Canada. Bicalutamide is given as part of a combination prostate cancer treatment with one other remedy that stops the testicles from producing testosterone.
Luteinizing hormone-releasing hormone (LHRH) agonists block the signal from the pituitary gland that tells the testicles to make testosterone. This included knowledge from medical trials (third evaluation of the primary research, after patients had been followed for over 7 years), stories of side effects and data printed in scientific journals.
Cease utilizing Casodex and name your doctor directly if you have any of these critical unintended effects: penis erection that's painful or lasts four hours or longer, severe dizziness or fainting. Use a Casodex coupon or discount card to save lots of in your prescription while you fill it on the pharmacy.
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bicalutamide online today (also referred to as GnRH agonists) are medicine that cause the pituitary gland to make extra LH. Eventually the pituitary gland stops responding to the LHRH agonist and the pituitary stops releasing LH. Because of this, the testicles cease making testosterone.
Late apoptosis of RMC cell strains affected by remedy of bicalutamide. Usually complaints of negative effects are disregarded by nurses, docs and sometimes referred out to other doctors. Sometimes casodex interactions for profit or to forestall an unlikely loss of life or metastization from low threat most cancers stands out as the primary or the one objectives of cancer remedy.
As of bicalutamide buy australia , these collaborative efforts between provinces and territories have resulted in over 200 completed joint negotiations on brand title medication and value reductions on over 60 generic drugs. Always inform your physician, nurse or pharmacist about any uncomfortable side effects you may have.
Nilutamide, however not flutamide or bicalutamide, has been related to alcohol intolerance in 3%-19% of patients in research involving both monotherapy or CAB 13 , 31 - 33 , 43 , forty four The intolerance takes the form of a slight disulfiram-like reaction, with hot flashes and pores and skin rash being the primary signs 32 The mechanism by which this response happens will not be identified.
Supplies accurate and unbiased data on greater than 24,000 pharmaceuticals, over-the-counter medicines and pure products. In sufferers receiving lenalidomide in combination with dexamethasone until progression or for 18 months, the hematologic SPM incidence charge (0.sixteen per one hundred individual-years) was not increased as in comparison with thalidomide together with melphalan and prednisone (0.seventy nine per a hundred individual-years).
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It is also utilized for the remedy of A number of Myeloma and Mantle Cell Lymphoma. Fourteen of the 15 studied specialty tier most cancers drugs are covered by all plans, and the median annual out-of-pocket cost for every of those medicine exceeds $8,000.
Revlimid has been proven to lengthen the time patients stay with out their disease getting worse. side effects of lenalidomide complain of pain and docs discover that part of the jaw bone has died. While lenalidomide and thalidomide are both accessible for myeloma remedy in Canada, lenalidomide has develop into the more widely used drug.
Nonetheless, the heterogeneity of the prior treatments and the completely different instances from illness analysis make the data much less interpretable. Topics eligible for this study will receive remedy with research drug for a maximum of eight 28-day treatment cycles, depending on the schedule of their final lenalidomide-containing routine.
Few research have assessed the lengthy-time period effects of treatment with lenalidomide plus dexamethasone in patients with RRMM, although obtainable research have constantly proven that long-time period treatment was efficient and well tolerated, with no improve in second main malignancies (SPMs) eleven - 13 The current research (MM-024) is each an extension of the MM-021 trial and a formal Extended Access Program (EAP), initiated to permit sufferers enrolled in MM-021 to continue remedy with Rd and, to collect efficacy and safety info.
best price for revlimid mustn't donate blood while taking lenalidomide and for 4 weeks after stopping remedy to stop fetal publicity by way of transfusion of pregnant ladies. Lenalidomide capsule can also be used along with dexamethasone to deal with individuals with a number of myeloma (a kind of cancer of the bone marrow) who've already been treated with at the very least one different medicine.
Humira's common US value elevated 15.9% over this period, after accounting for rebates and other concessions, in the end costing American sufferers and insurers an estimated $1.86 billion greater than what would have been spent if Humira's worth had not increased.
However, clinical pointers advocate Revlimid for individuals who've taken other medicines to deal with Hodgkin lymphoma however still have the situation. 2. getting off revlimid , Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C, Chauhan D, Okawa Y, Munshi NC, Richardson PG, Anderson KC. Lenalidomide inhibits osteoclastogenesis, survival elements and bone-remodeling markers in multiple myeloma.
There's just one drawback: Revlimid costs $12,000 per month, and it is not covered by the Ontario authorities's drug program. This medication lowers the variety of some forms of blood cells in your body. lenalidomide other names predicted the response of three-quarters of the patients within the validation set to lenalidomide.
Subsequently, in response to the primary spherical of clarification between the producer and the ERG, the manufacturer adjusted the hazard ratio for patient characteristics, by adjusting at some stage in a number of myeloma observed within the Taverna et al. research.
Sorafenib is a cancer remedy that interferes with the expansion and spread of cancer cells in the body. Mumbai: The Bombay high court docket on Tuesday dismissed a problem by Bayer AG in opposition to a choice to permit drug maker Natco Pharma Ltd to fabricate and promote a generic copy of a patent-protected cancer drug made by the German company. price of nexavar tablet of the TKI should be decreased when the next medication are used in mixture with ketoconazole: axitinib, dasatinib, erlotinib, lapatinib, nilotinib, pazopanib, ruxolitinib, and sunitinib.
Natco's drug is to be used only in India, the choice said. As well as, one patient with hurthle cell cancer was deemed not appropriate for iodine therapy because of large-volume illness adjoining to an airway. sorafenib generic
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NEXAVAR may trigger fetal harm when administered to a pregnant lady see Use in Specific Populations (8.1). Advise females of reproductive potential to make use of effective contraception throughout remedy and for 6 months following the final dose of NEXAVAR.
This drug is accredited as a first remedy for HCC that can not be eliminated by surgery. nexavar online purchase affiliate with different dispensaries that ship products to our prospects from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and the United Kingdom.
nexavar side effects on disease progression was high in each trials (CHOOSE: 87.eight%, DETERMINATION: 75%) 24 , 25 As well as, in each trials, patients in both arm had been also eligible to obtain subsequent anti-most cancers therapies that weren't a part of the trial protocols 24 , 25 In the CHOOSE trial, at the primary information-minimize, 15.7% of sufferers randomized to lenvatinib and 12.2% of patients randomized to placebo, had received subsequent therapy (knowledge from CSR) including therapy with another TKI (information from CSR).
In what is the cost of sorafenib , two studies showed that sorafenib, a multi-goal tyrosine kinase inhibitor, improved general survival in HCC by roughly 3 months compared to placebo ( 8 , 9 ). These results were recently challenged by a evaluate of the Surveillance, Epidemiology, and Finish Outcomes-Medicare database which showed an insignificant difference in 3-month mortality between patients treated with sorafenib and people treated with placebo ( 10 ). Nonetheless, knowledge are lacking for African-American and Hispanic patients, as these research enrolled primarily Caucasian and Asian patients.

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